Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key insights into the specific function of individual...

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Bibliographic Details
Main Authors: Gaspare La Rocca, Bryan King, Bing Shui, Xiaoyi Li, Minsi Zhang, Kemal M Akat, Paul Ogrodowski, Chiara Mastroleo, Kevin Chen, Vincenzo Cavalieri, Yilun Ma, Viviana Anelli, Doron Betel, Joana Vidigal, Thomas Tuschl, Gunter Meister, Craig B Thompson, Tullia Lindsten, Kevin Haigis, Andrea Ventura
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
microRNA
RISC
argonaute
T6B
miRISC
TNRC6
Online Access:https://elifesciences.org/articles/70948

Internet

https://elifesciences.org/articles/70948

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