Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key insights into the specific function of individual...
Main Authors: | Gaspare La Rocca, Bryan King, Bing Shui, Xiaoyi Li, Minsi Zhang, Kemal M Akat, Paul Ogrodowski, Chiara Mastroleo, Kevin Chen, Vincenzo Cavalieri, Yilun Ma, Viviana Anelli, Doron Betel, Joana Vidigal, Thomas Tuschl, Gunter Meister, Craig B Thompson, Tullia Lindsten, Kevin Haigis, Andrea Ventura |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-08-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/70948 |
Similar Items
-
Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins
by: Katherine S. Bridge, et al.
Published: (2017-07-01) -
Induction de l'expression génique par des petits ARN dans des cellules de mammifère
by: Liang, Feifei
Published: (2011) -
The Role of Dynamic miRISC During Neuronal Development
by: Bharti Nawalpuri, et al.
Published: (2020-01-01) -
E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity
by: Jie-Ning Li, et al.
Published: (2021-07-01) -
RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana
by: Zhonghui Zhang, et al.
Published: (2017-05-01)