Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Summary: Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that control these changes are largely unknown. Using ChIP-seq for specific histone post-translational modifications (PTMs), we mapped t...

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Bibliographic Details
Main Authors: Brendan E. Russ, Moshe Olshansky, Jasmine Li, Michelle L.T. Nguyen, Linden J. Gearing, Thi H.O. Nguyen, Matthew R. Olson, Hayley A. McQuilton, Simone Nüssing, Georges Khoury, Damian F.J. Purcell, Paul J. Hertzog, Sudha Rao, Stephen J. Turner
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317795

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http://www.sciencedirect.com/science/article/pii/S2211124717317795

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