KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

Abstract Background Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3) are implicated in Ca2+ brain homeostasis; normally, they extrude C...

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Bibliographic Details
Main Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins, Carlos Beas-Zarate
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Biomedical Science
Subjects:
Monosodium glutamate
NCX1-3
KB-R7943
Seizures
Hippocampus
Entorhinal cortex
Online Access:http://link.springer.com/article/10.1186/s12929-017-0335-y

Internet

http://link.springer.com/article/10.1186/s12929-017-0335-y

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