Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro

Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro

In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295, and 14 related tetrahydroquinoxaline analogues against Haemonchus contortus was explored. These compounds were screened against parasitic larvae - exsheathed third-stage (xL3) and fourth-stage (L4) - using...

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Bibliographic Details
Main Authors: Yaqing Jiao, Sarah Preston, Jose F. Garcia-Bustos, Jonathan B. Baell, Sabatino Ventura, Thuy Le, Nicole McNamara, Nghi Nguyen, Antony Botteon, Cameron Skinner, Jill Danne, Sarah Ellis, Anson V. Koehler, Tao Wang, Bill C.H. Chang, Andreas Hofmann, Abdul Jabbar, Robin B. Gasser
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320718301568

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http://www.sciencedirect.com/science/article/pii/S2211320718301568

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