HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

HOXA9 is often highly expressed in leukemias. However, its precise roles in leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression for multiple anti-apoptotic pathways to promote leukemogenesis. In MLL fusion-mediated leukemia, MLL fusion directly activates the expression...

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Bibliographic Details
Main Authors: Ryo Miyamoto, Akinori Kanai, Hiroshi Okuda, Yosuke Komata, Satoshi Takahashi, Hirotaka Matsui, Toshiya Inaba, Akihiko Yokoyama
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
HOXA9
MYC
leukemia
apoptosis
transcription
Online Access:https://elifesciences.org/articles/64148

Internet

https://elifesciences.org/articles/64148

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