Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

The earliest methods of genome editing, such as zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs), utilize customizable DNA-binding motifs to target the genome at specific loci. While these approaches provided sequence-specific gene-editing capacity, the labori...

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Bibliographic Details
Main Authors: Marlo K. Thompson, Robert W. Sobol, Aishwarya Prakash
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biology
Subjects:
CRISPR
gene editing
base excision repair
mismatch repair
homologous recombination
non-homologous end-joining
Online Access:https://www.mdpi.com/2079-7737/10/6/530

Internet

https://www.mdpi.com/2079-7737/10/6/530

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