The Precise Diagnosis of Wolfram Syndrome Type 1 Based on Next-Generation Sequencing

The Precise Diagnosis of Wolfram Syndrome Type 1 Based on Next-Generation Sequencing

Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population.Methods: We analyzed 279 patients with unexplained optic atrophy using next-generation sequencing. All patients underwent d...

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Bibliographic Details
Main Authors: Dan-Dan Wang, Fang-Yuan Hu, Feng-Juan Gao, Sheng-Hai Zhang, Ping Xu, Guo-Hong Tian, Ji-Hong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
wolfram syndrome
WFS1
optic atrophy
diabetes mellitus
next-generation sequencing
precise diagnosis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01217/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01217/full

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