Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival

Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival

Summary: Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation. However, contradicting in vitro data suggest a different view on physiological significance of FSHR-mediated cAMP signaling. We found that the...

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Bibliographic Details
Main Authors: Livio Casarini, Clara Lazzaretti, Elia Paradiso, Silvia Limoncella, Laura Riccetti, Samantha Sperduti, Beatrice Melli, Serena Marcozzi, Claudia Anzivino, Niamh S. Sayers, Jakub Czapinski, Giulia Brigante, Francesco Potì, Antonio La Marca, Francesco De Pascali, Eric Reiter, Angela Falbo, Jessica Daolio, Maria Teresa Villani, Monica Lispi, Giovanna Orlando, Francesca G. Klinger, Francesca Fanelli, Adolfo Rivero-Müller, Aylin C. Hanyaloglu, Manuela Simoni
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Molecular Biology
Female Reproductive Endocrinology
Endocrine Regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310099

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http://www.sciencedirect.com/science/article/pii/S2589004220310099

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