Comparison of Different Liver Test Thresholds for Drug-Induced Liver Injury: Updated RUCAM versus Other Methods

Comparison of Different Liver Test Thresholds for Drug-Induced Liver Injury: Updated RUCAM versus Other Methods

According to the updated Roussel Uclaf Causality Assessment Method (RUCAM), drug-induced liver injury (DILI) is currently defined based on thresholds of alanine aminotransferase (ALT) levels above 5 × the upper limit of normal (ULN) and/or alkaline phosphatase (ALP) levels greater than 2 × the ULN....

Full description

Bibliographic Details
Main Authors: Hongyi Yang, Daihong Guo, Yuanjie Xu, Man Zhu, Chong Yao, Chao Chen, Wangping Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
drug-induced liver injury
thresholds comparison
fluoroquinolones
active surveillance
pharmacovigilance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00816/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00816/full

Similar Items