Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. Analysis of DENND1-Rab35, Rabex-Rab5, TRAP...

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Bibliographic Details
Main Authors: Lars Langemeyer, Ricardo Nunes Bastos, Yiying Cai, Aymelt Itzen, Karin M Reinisch, Francis A Barr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
membrane traffic
Rab GTPase
nucleotide exchange factor
Online Access:https://elifesciences.org/articles/01623

Internet

https://elifesciences.org/articles/01623

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