Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB

Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB

Calycosin, an isoflavonoid phytoestrogen, isolated from Radix Astragali, was reported to possess anti-tumor, anti-inflammation, and osteogenic properties, but its impact on osteoclast differentiation remains unclear. In this study, we examined the effects of calycosin on osteoclastogenesis induced b...

Full description

Bibliographic Details
Main Authors: Gui-Hua Quan, Hongbing Wang, Jinjin Cao, Yuxin Zhang, Donglin Wu, Qisheng Peng, Ning Liu, Wan-Chun Sun
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
calycosin
osteoclast
bone resorption
NFATc1
c-Fos
NF-κB
MAPKs
Online Access:http://www.mdpi.com/1422-0067/16/12/26179

Internet

http://www.mdpi.com/1422-0067/16/12/26179

Similar Items