Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer

Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer

Deregulated cellular apoptosis is a hallmark of cancer and chemotherapy resistance. The B-cell lymphoma 2 (BCL-2) protein family members are sentinel molecules that regulate the mitochondrial apoptosis machinery and arbitrate cell fate through a delicate balance between pro- and anti-apoptotic facto...

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Bibliographic Details
Main Authors: Natalie Yan Li Ngoi, Clarice Choong, Joanne Lee, Gregory Bellot, Andrea Li Ann Wong, Boon Cher Goh, Shazib Pervaiz
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
apoptosis
targeted therapy
cancer therapeutics
bcl-2
mcl-1
bcl-xl
Online Access:https://www.mdpi.com/2072-6694/12/3/574

Internet

https://www.mdpi.com/2072-6694/12/3/574

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