HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice.

Hepatitis C virus (HCV) is a blood-borne pathogen and a major cause of liver disease worldwide. Gene expression profiling was used to characterize the transcriptional response to HCV H77c infection. Evidence is presented for activation of innate antiviral signaling pathways as well as induction of l...

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Bibliographic Details
Main Authors: Michael A Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S Doyle, Michael G Katze, D Lorne Tyrrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2647842?pdf=render