Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediat...

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Bibliographic Details
Main Authors: Xiaoping Wang, Chun Li, Qiyan Wang, Weili Li, Dongqing Guo, Xuefeng Zhang, Mingyan Shao, Xu Chen, Lin Ma, Qian Zhang, Wei Wang, Yong Wang
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
tanshinone IIA
doxorubicin
autophagic flux
Beclin1
LAMP1
Online Access:https://www.mdpi.com/2072-6694/11/7/910

Internet

https://www.mdpi.com/2072-6694/11/7/910

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