Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution

Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution

Hyperthermic intraperitoneal chemoperfusion (HIPEC) is an established form of locoregional chemotherapy of peritoneum tumors. However, its efficacy and safety status remain a controversy, partially, due to scarce data on pharmacokinetics and toxicity profile of drugs under HIPEC. In the current stud...

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Bibliographic Details
Main Authors: Galina Kireeva, Stepan Kruglov, Mikhail Maydin, Ekaterina Gubareva, Elena Fedoros, Ekaterina Zubakina, Natalya Ivanenko, Marina Bezruchko, Nikolay Solovyev
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
<i>cis</i>-diamminedichloridoplatinum (II)
hyperthermic intraperitoneal chemoperfusion
Wistar rats
platinum protein binding
intravenous injection
inductively coupled plasma mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/25/20/4733

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https://www.mdpi.com/1420-3049/25/20/4733

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