The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis

The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis

Background: Meropenem is being investigated for repurposing as an anti-tuberculosis drug. This study aimed to develop a meropenem population pharmacokinetics model in patients with pulmonary tuberculosis and identify covariates explaining inter-individual variability.Methods: Patients were randomize...

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Bibliographic Details
Main Authors: Ahmed A. Abulfathi, Veronique de Jager, Elana van Brakel, Helmuth Reuter, Nikhil Gupte, Naadira Vanker, Grace L. Barnes, Eric Nuermberger, Susan E. Dorman, Andreas H. Diacon, Kelly E. Dooley, Elin M. Svensson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
meropenem
population pharmacokinetic (PK) model
tuberculosis
pharmacokinetics analysis
drug sensitive TB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.637618/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.637618/full

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