A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy

A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy

Context: Androgen deprivation therapy (ADT) in prostate cancer results in muscular atrophy, due to loss of the anabolic actions of testosterone. Recently, we discovered that testosterone acts on the hepatic urea cycle to reduce amino acid nitrogen elimination. We now hypothesize that ADT enhances pr...

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Bibliographic Details
Main Authors: Teresa Lam, Mark McLean, Amy Hayden, Anne Poljak, Birinder Cheema, Howard Gurney, Glenn Stone, Neha Bahl, Navneeta Reddy, Haleh Shahidipour, Vita Birzniece
Format: Article
Language:English
Published: Bioscientifica 2019-05-01
Series:Endocrine Connections
Subjects:
testosterone
sarcopenia
hypogonadism
prostate cancer
urea production
Online Access:https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0179.xml

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https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0179.xml

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