A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy
Context: Androgen deprivation therapy (ADT) in prostate cancer results in muscular atrophy, due to loss of the anabolic actions of testosterone. Recently, we discovered that testosterone acts on the hepatic urea cycle to reduce amino acid nitrogen elimination. We now hypothesize that ADT enhances pr...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Bioscientifica
2019-05-01
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Series: | Endocrine Connections |
Subjects: | |
Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0179.xml |