A Novel Claudinopathy Based on Claudin-10 Mutations

A Novel Claudinopathy Based on Claudin-10 Mutations

Claudins are key components of the tight junction, sealing the paracellular cleft or composing size-, charge- and water-selective paracellular channels. Claudin-10 occurs in two major isoforms, claudin-10a and claudin-10b, which constitute paracellular anion or cation channels, respectively. For sev...

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Bibliographic Details
Main Author: Susanne Milatz
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
tight junction
paracellular permeability
paracellular sodium transport
thick ascending limb
nephropathy
helix syndrome
hypokalemia
hypermagnesemia
anhidrosis
gland dysfunction
Online Access:https://www.mdpi.com/1422-0067/20/21/5396

Internet

https://www.mdpi.com/1422-0067/20/21/5396

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