Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions

Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions

Phosphodiesterase 7 (PDE7), a cAMP-specific PDE family, insensitive to rolipram, is present in many immune cells, including T lymphocytes. Two genes of PDE7 have been identified: PDE7A and PDE7B with three or four splice variants, respectively. Both PDE7A and PDE7B are expressed in T cells, and the...

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Bibliographic Details
Main Author: Marianna Szczypka
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
allergic and autoimmune diseases
intracellular cAMP
families of PDE
phosphodiesterase 7
PDE7
selective PDE inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/17/6118

Internet

https://www.mdpi.com/1422-0067/21/17/6118

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