A Pediatric Case of Glioblastoma Multiforme Associated With a Novel Germline p.His112CysfsTer9 Mutation in the MLH1 Gene Accompanied by a p.Arg283Cys Mutation in the TP53 Gene: A Case Report

A Pediatric Case of Glioblastoma Multiforme Associated With a Novel Germline p.His112CysfsTer9 Mutation in the MLH1 Gene Accompanied by a p.Arg283Cys Mutation in the TP53 Gene: A Case Report

Targeted gene panel testing has the power to interrogate hundreds of genes and evaluate the genetic risk for many types of hereditary cancers simultaneously. We screened a 13-year-old male patient diagnosed with glioblastoma multiforme with the aim to get further insights into the biology of his con...

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Bibliographic Details
Main Authors: Aleksandra Stajkovska, Sanja Mehandziska, Rodney Rosalia, Margarita Stavrevska, Marija Janevska, Martina Markovska, Ivan Kungulovski, Zan Mitrev, Goran Kungulovski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Genetics
Subjects:
next-generation sequencing
North Macedonia
hereditary cancer syndromes
Lynch syndrome
TP53
MLH1
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00952/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00952/full

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