Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection

Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection

Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of infectious, autoimmune, and cancer-related diseases. However, the discovery, development, and manufacturing processes are complex, resource-consuming activities that preclude the rapid deployment of mAbs in outbrea...

Full description

Bibliographic Details
Main Authors: Jesse H. Erasmus, Jacob Archer, Jasmine Fuerte-Stone, Amit P. Khandhar, Emily Voigt, Brian Granger, Robin G. Bombardi, Jennifer Govero, Qing Tan, Lorellin A. Durnell, Rhea N. Coler, Michael S. Diamond, James E. Crowe, Jr., Steven G. Reed, Larissa B. Thackray, Robert H. Carnahan, Neal Van Hoeven
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Gene-encoded antibody
monoclonal antibody
RNA therapeutic
RNA delivery
antibody delivery
replicon
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301352

Internet

http://www.sciencedirect.com/science/article/pii/S2329050120301352

Similar Items