Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines, and cardiac hypertrophy are co-existing features of SCD, no mechanistic links between these features have been demons...

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Bibliographic Details
Main Authors: Oluwabukola T. Gbotosho, Maria G. Kapetanaki, Samit Ghosh, Flordeliza S. Villanueva, Solomon F. Ofori-Acquah, Gregory J. Kato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
heme
hemolysis
sickle cell disease
IL-6
inflammation
cardiac hypertrophy genes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01910/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01910/full

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