Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting inflammatory responses in inflammatory bowel disea...

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Bibliographic Details
Main Authors: J Jasper Deuring, Meng Li, Wanlu Cao, Sunrui Chen, Wenshi Wang, Colin de Haar, C Janneke van der Woude, Maikel Peppelenbosch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221924

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https://doi.org/10.1371/journal.pone.0221924

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