Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes.

Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes.

Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the treatment of several solid tumors (gastro-intestinal, gynecological, head and neck, breast carcinomas). Therapy with flu...

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Bibliographic Details
Main Authors: Chiara Focaccetti, Antonino Bruno, Elena Magnani, Desirée Bartolini, Elisa Principi, Katiuscia Dallaglio, Eraldo O Bucci, Giovanna Finzi, Fausto Sessa, Douglas M Noonan, Adriana Albini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4324934?pdf=render

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http://europepmc.org/articles/PMC4324934?pdf=render

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