Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we d...

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Bibliographic Details
Main Authors: Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J.M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F.A. Wessels, Karin E. de Visser
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
breast cancer
ccl2
immunosuppression
neutrophils
tumor-induced inflammation
tumor-associated macrophages
γδ t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1334744

Internet

http://dx.doi.org/10.1080/2162402X.2017.1334744

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