AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design

Abstract The CRISPR/Cas system is a highly specific genome editing tool capable of distinguishing alleles differing by even a single base pair. Target sites might carry genetic variations that are not distinguishable by sgRNA designing tools based on one reference genome. AlleleAnalyzer is an open-s...

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Bibliographic Details
Main Authors: Kathleen C. Keough, Svetlana Lyalina, Michael P. Olvera, Sean Whalen, Bruce R. Conklin, Katherine S. Pollard
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Genome Biology
Subjects:
CRISPR
sgRNA design
Genomics
Genome surgery
Genome editing
Computational biology
Online Access:http://link.springer.com/article/10.1186/s13059-019-1783-3

Internet

http://link.springer.com/article/10.1186/s13059-019-1783-3

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