Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model

Ample evidence suggests that α-synuclein is released from cells and propagated from one area of the brain to others via cell-to-cell transmission. In terms of their prion-like behavior, α-synuclein propagation plays key roles in the pathogenesis and progression of α-synucleinopathies. Using α-synucl...

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Bibliographic Details
Main Authors: Se Hee Oh, Ha Na Kim, Hyun Jung Park, Jin Young Shin, Eun-Jin Bae, Mun Kyung Sunwoo, Seung-Jae Lee, Phil Hyu Lee
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015314