Utilization of genomic signatures to identify phenotype-specific drugs.

Genetic and genomic studies highlight the substantial complexity and heterogeneity of human cancers and emphasize the general lack of therapeutics that can match this complexity. With the goal of expanding opportunities for drug discovery, we describe an approach that makes use of a phenotype-based...

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Bibliographic Details
Main Authors: Seiichi Mori, Jeffrey T Chang, Eran R Andrechek, Anil Potti, Joseph R Nevins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2729377?pdf=render