Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3

Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3

A novel pathway of vitamin D activation by CYP11A has previously been elucidated. To define the mechanism of action of its major dihydroxy-products, we tested the divergence and overlap between the gene expression profiles of human epidermal keratinocytes treated with either CYP11A1-derived 20,23(OH...

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Bibliographic Details
Main Authors: Andrzej T. Slominski, Tae-Kang Kim, Zorica Janjetovic, Anna A. Brożyna, Michal A. Żmijewski, Hui Xu, Thomas R. Sutter, Robert C. Tuckey, Anton M. Jetten, David K. Crossman
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D
dihydroxyvitamin D
epidermal keratinocytes
nuclear receptor signaling
microarray
Online Access:http://www.mdpi.com/1422-0067/19/10/3072

Internet

http://www.mdpi.com/1422-0067/19/10/3072

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