Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis.

Evolutionarily conserved mechanisms maintain homeostasis of essential elements, and are believed to be highly time-variant. However, current approaches measure elemental biomarkers at a few discrete time-points, ignoring complex higher-order dynamical features. To study dynamical properties of eleme...

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Bibliographic Details
Main Authors: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Claudia Figueroa-Romero, Kristen A Mikhail, Tatiana M Botero, Stephen A Goutman, Eva L Feldman, Manish Arora
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007773