Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1

Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1

ObjectiveAutoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major disease components and is, to date, mainly explained by the presence of neutrali...

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Bibliographic Details
Main Authors: Øyvind Bruserud, Eirik Bratland, Alexander Hellesen, Nicolas Delaleu, Håkon Reikvam, Bergithe E. Oftedal, Anette S. B. Wolff
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
autoimmune polyendocrine syndrome type 1
chronic mucocutaneous candidiasis
monocytes
IL-17
IL-22
IL-23
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01074/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01074/full

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