Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes

Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes

Antipsychotics are a first-line treatment for psychotic disorders. The cytochrome P450 isoenzymes CYP3A4/5 and CYP2D6 metabolize most antipsychotics. The activity of these isoenzymes in children changes with maturation, so it is different from that in adults. Objective: to study the associations of...

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Bibliographic Details
Main Authors: D. V. Ivashchenko, A. S. Osipov, E. V. Nazarova, M. A. Ovchinnikova, N. I. Buromskaya, V. V. Smirnov, P. V. Shimanov, R. V. Deitch, T. A. Fainshtein, E. N. Shagovenko, K. A. Akmalova, A. A. Kachanova, E. A. Grishina, L. M. Savchenko, Yu. S. Shevchenko, D. A. Sychev
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2020-12-01
Series:Nevrologiâ, Nejropsihiatriâ, Psihosomatika
Subjects:
cyp450, cyp2d6, and cyp3a phenotyping
antipsychotics
adolescents
safety
efficacy
Online Access:https://nnp.ima-press.net/nnp/article/view/1466

Internet

https://nnp.ima-press.net/nnp/article/view/1466

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