Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metaboli...

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Bibliographic Details
Main Authors: Glenn E. Simmons, Wendy M. Pruitt, Kevin Pruitt
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
sirtuin
SIRT1
metabolism
cancer
lipolysis
lipids
steatosis
fatty acid
sterol regulatory element-binding protein (SREBP)
Online Access:http://www.mdpi.com/1422-0067/16/1/950

Internet

http://www.mdpi.com/1422-0067/16/1/950

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