Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases.

CONTEXT:There are growing concerns about effect size inflation and replication validity of association studies, but few observational investigations have explored the extent of these problems. OBJECTIVE:Using meta-analyses to measure the reliability of initial studies and explore whether this varies...

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Bibliographic Details
Main Authors: Estelle Dumas-Mallet, Katherine Button, Thomas Boraud, Marcus Munafo, François Gonon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4919034?pdf=render