Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm

Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm

Abstract Bicuspid aortic valve (BAV) is frequently associated with the development of ascending aortic aneurysm, even if the underlying mechanisms remain to be clarified. Here, we investigated if a deregulation of Notch1 signaling pathway and endothelial progenitor cells (EPCs) number is associated...

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Bibliographic Details
Main Authors: Carmela R. Balistreri, Floriana Crapanzano, Leonardo Schirone, Alberto Allegra, Calogera Pisano, Giovanni Ruvolo, Maurizio Forte, Ernesto Greco, Elena Cavarretta, Antonino G. M. Marullo, Sebastiano Sciarretta, Giacomo Frati
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Endothelial Progenitor Cells (EPC)
Ascending Aorta Aneurysm (AAA)
Bicuspid Aortic Valve (BAV)
Notch Signaling Pathway
Tricuspid Aortic Valve (TAV)
Online Access:https://doi.org/10.1038/s41598-018-32170-2

Internet

https://doi.org/10.1038/s41598-018-32170-2

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