Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells

Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells

Background Abnormal proliferation of vascular smooth muscle cells (VSMC) is a major cause of cardiovascular diseases (CVDs). Many studies suggest that vascular injury triggers VSMC dedifferentiation, which results in VSMC changes from a contractile to a synthetic phenotype; however, the underlying m...

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Bibliographic Details
Main Authors: Chien-Hung Huang, Jin-Shuei Ciou, Shun-Tsung Chen, Victor C. Kok, Yi Chung, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chi-Ying F. Huang, Ka-Lok Ng
Format: Article
Language:English
Published: PeerJ Inc. 2016-09-01
Series:PeerJ
Subjects:
Drug repositioning
Cardiovascular disease
Gaussian graphical model
Vascular smooth muscle cell
Gene set enrichment analysis
Topological parameters
Online Access:https://peerj.com/articles/2478.pdf

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https://peerj.com/articles/2478.pdf

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