Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

Huntington's disease (HD) patients and mouse models show learning and memory impairment even before the onset of motor symptoms. Deficits in hippocampal synaptic plasticity have been involved in the HD memory impairment. Several studies show that prostaglandin E2 (PGE2) EP2 receptor stimulates...

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Bibliographic Details
Main Authors: Marta Anglada-Huguet, Laura Vidal-Sancho, Albert Giralt, Gerardo García-Díaz Barriga, Xavier Xifró, Jordi Alberch
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Hippocampus,
Huntingtin,
Misoprostol,
PSD-95
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300474

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115300474

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