Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models

Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis that may be a promising agent in cancer therapy due to its selectivity toward tumor cells. However, many cancer cells are resistant to TRAIL due to defects in apoptosis signaling or activation of surviva...

Full description

Bibliographic Details
Main Authors: Devalingam Mahalingam, Jennifer S. Carew, Claudia M. Espitia, Robbert H. Cool, Francis J. Giles, Steven de Jong, Steffan T. Nawrocki
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
TRAIL
Apoptosis
sunitinib
XIAP
colon cancer
Online Access:https://www.mdpi.com/2072-6694/11/7/895

Internet

https://www.mdpi.com/2072-6694/11/7/895

Similar Items