YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA

YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA

Hepatocellular carcinoma (HCC) is a typical hypervascular solid tumor that requires neoangiogenesis for growth. The vascular endothelial growth factor (VEGF) is the most potent proangiogenic factor in neovascularization. The multifunctional Yin-Yang 1 (YY1) is involved in the regulation of tumor mal...

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Bibliographic Details
Main Authors: Wendong Yang, Zhongwei Li, Rong Qin, Xiaorui Wang, Huihui An, Yule Wang, Yan Zhu, Yantao Liu, Shijiao Cai, Shuang Chen, Tao Sun, Jing Meng, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
YY1
angiogenesis
vascular endothelial growth factor A
transcription activation
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01187/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01187/full

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