Indomethacin-Induced Apoptosis in Esophageal Adenocarcinoma Cells Involves Upregulation of Bax and Translocation of Mitochondrial Cytochrome C Independent of COX-2 Expression

Indomethacin-Induced Apoptosis in Esophageal Adenocarcinoma Cells Involves Upregulation of Bax and Translocation of Mitochondrial Cytochrome C Independent of COX-2 Expression

The prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to exert a chemopreventive effect in esophageal and other gastrointestinal tumors. The precise mechanism by which this occurs, however, is unknown. While the inhibition of COX-2 as a potential explanation for this che...

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Bibliographic Details
Main Authors: Sanjeev Aggarwal, Neelam Taneja, Lin Lin, Mark B. Orringer, Alnawaz Rehemtulla, David G. Beer
Format: Article
Language:English
Published: Elsevier 2000-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
esophageal adenocarcinoma
Barrett's esophagus
NSAIDs
chemoprevention
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860080007X

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http://www.sciencedirect.com/science/article/pii/S147655860080007X

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