Facile Synthesis of Novel Coumarin Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study, ADMET Prediction and Toxicity Study

Facile Synthesis of Novel Coumarin Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study, ADMET Prediction and Toxicity Study

The work reports the synthesis under solvent-free condition using the ionic liquid [Et3NH][HSO4] as a catalyst of fifteen novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)-methyl)-4-hydroxy-2H-chromen-2-onederivatives 4a–o as potential antimicrobial agents. The structures of the synthesized c...

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Bibliographic Details
Main Authors: Shailee V. Tiwari, Julio A. Seijas, Maria Pilar Vazquez-Tato, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
ionic liquid
antifungal activity
antibacterial activity
molecular docking
cytotoxicity
in vivo acute oral toxicity
Online Access:https://www.mdpi.com/1420-3049/22/7/1172

Internet

https://www.mdpi.com/1420-3049/22/7/1172

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