Absence of CX3CR1 impairs the internalization of Tau by microglia

Absence of CX3CR1 impairs the internalization of Tau by microglia

Abstract Background Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. Methods We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5...

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Bibliographic Details
Main Authors: Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avila
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Alzheimer’s disease
Tauopathies
CX3CR1
Phagocytosis
Microglia
Online Access:http://link.springer.com/article/10.1186/s13024-017-0200-1

Internet

http://link.springer.com/article/10.1186/s13024-017-0200-1

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