Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in consolidation. But less is known about the functio...

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Bibliographic Details
Main Authors: Susan McQuown, Shouzhen Xia, Karsten Baumgärtel, Richard Barido, Gary Anderson, Brian Dyck, Roderick Scott, Marco Peters
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PDE1
PDE1B
phosphodiesterase (PDE)
memory consolidation
spatial memory
Barnes Maze
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00021/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00021/full

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