Dysferlin-peptides reallocate mutated dysferlin thereby restoring function.

Dysferlin-peptides reallocate mutated dysferlin thereby restoring function.

Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, LGMD2B. There is no therapy. Dysferlin is a membrane protein comprised of seven, beta-sheet enriched, C2 domains and is involved in Ca(2+)dependent sarcolemmal repair after minute wounding. On the pro...

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Bibliographic Details
Main Authors: Verena Schoewel, Andreas Marg, Severine Kunz, Tim Overkamp, Romy Siegert Carrazedo, Ute Zacharias, Peter T Daniel, Simone Spuler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185377/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185377/pdf/?tool=EBI

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