Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

Ferroptosis is a programmed iron-dependent cell death associated with peroxidation of lipids particularly, phospholipids. Several studies suggested a possible contribution of mitochondria to ferroptosis although the mechanisms underlying mitochondria-mediated ferroptotic pathways remain elusive. Red...

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Bibliographic Details
Main Authors: Sehwan Jang, Xavier R. Chapa-Dubocq, Yulia Y. Tyurina, Claudette M. St Croix, Alexandr A. Kapralov, Vladimir A. Tyurin, Hülya Bayır, Valerian E. Kagan, Sabzali Javadov
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Redox Biology
Subjects:
Ferroptosis
Heart
Mitochondria
Glutathione
Oxidized phosphatidylethanolamine
Ischemia-reperfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001798

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http://www.sciencedirect.com/science/article/pii/S2213231721001798

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