Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

<p>Abstract</p> <p>Background</p> <p>Prolonged elevated levels of lipids have negative effects on beta-cell function and mass (lipotoxicity). To what extent exposure to high glucose concentration is important in the harmful effects of lipids (glucolipotoxicity) has been...

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Bibliographic Details
Main Authors: Bergsten Peter, Sargsyan Ernest
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Lipids in Health and Disease
Subjects:
beta-cell
human islets
lipotoxicity
apoptosis
palmitate oxidation
Online Access:http://www.lipidworld.com/content/10/1/115

Internet

http://www.lipidworld.com/content/10/1/115

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