RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

Abstract Background There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression...

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Bibliographic Details
Main Authors: Jiyoun Yeo, Diego A. Morales, Tian Chen, Erin L. Crawford, Xiaolu Zhang, Thomas M. Blomquist, Albert M. Levin, Pierre P. Massion, Douglas A. Arenberg, David E. Midthun, Peter J. Mazzone, Steven D. Nathan, Ronald J. Wainz, Patrick Nana-Sinkam, Paige F. S. Willey, Taylor J. Arend, Karanbir Padda, Shuhao Qiu, Alexei Federov, Dawn-Alita R. Hernandez, Jeffrey R. Hammersley, Youngsook Yoon, Fadi Safi, Sadik A. Khuder, James C. Willey
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Pulmonary Medicine
Subjects:
COPD
eQTL
cis-regulation
GWAS
ERCC5
CAT
Online Access:http://link.springer.com/article/10.1186/s12890-018-0603-y

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http://link.springer.com/article/10.1186/s12890-018-0603-y

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