Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization

Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization

Mice transplanted with human cord blood-derived hematopoietic stem cells (HSCs) became a powerful experimental tool for studying the heterogeneity of human immune reconstitution and immune responses in vivo. Yet, analyses of human T cell maturation in humanized models have been hampered by an overal...

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Bibliographic Details
Main Authors: Valery Volk, Andreas I. Reppas, Philippe A. Robert, Loukia M. Spineli, Bala Sai Sundarasetty, Sebastian J. Theobald, Andreas Schneider, Laura Gerasch, Candida Deves Roth, Stephan Klöss, Ulrike Koehl, Constantin von Kaisenberg, Constanca Figueiredo, Haralampos Hatzikirou, Michael Meyer-Hermann, Renata Stripecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
hematopoietic stem cell transplantation
cord blood
dendritic cell
T cell maturation
lymphatic
humanized mice
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01709/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01709/full

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