Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human hematopoiesis and model hematological malignancies. Transgenic technologies enable the generation of specific leukemia types by the expression of human oncogenes under specific promoters. Using this technolo...

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Bibliographic Details
Main Authors: Daniela Zizioli, Simona Bernardi, Marco Varinelli, Mirko Farina, Luca Mignani, Katia Bosio, Dario Finazzi, Eugenio Monti, Nicola Polverelli, Michele Malagola, Elisa Borsani, Giuseppe Borsani, Domenico Russo
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
zebrafish
chronic myeloid leukemia (CML)
BCR-ABL1
transgenic animal model
UAS/hsp70-Gal4
embryonic development
Online Access:https://www.mdpi.com/2073-4409/10/2/445

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https://www.mdpi.com/2073-4409/10/2/445

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